Asia-Pacific Journal of Pharmacotherapy & Toxicology

Research Article | Open Access

Experience with non-drug strategies in women with metabolic syndrome during the menopausal transition: a focus on cardiovascular risk

R.R. Berikhanova 1, I.A. Minenko 2, S.A. Bondarev3

1Federal State Budgetary Institution “Central Clinical Hospital of Civil Aviation”, Moscow, Russia.

2Department of Integrative Medicine FGAOU VO "First Moscow State Medical University named after I.M. Sechenov", Moscow, Russia.

3Cardiologist of the rehabilitation clinic of the University Clinical Hospital №2 FGAOU VO "First Moscow State Medical University named after I.M. Sechenov", Moscow, Russia.

*Correspondence: Berikhanova Rumisa Ramzanovn (Obstetriciangynecologist, Central Clinical Hospital of Civil Aviation; Applicant, Department of Integrative Medicine, I.M. Sechenov First Moscow State Medical University; Federal State Budgetary Institution “Central Clinical Hospital of Civil Aviation”, Moscow, Russia; E-mail: rumiska07@mail.ru).

Asia-Pacific Journal of Pharmacotherapy & Toxicology 2021, 1(1): 1-18. https://doi.org/10.32948/ajpt.2021.03.10

Received: 26 Jan 2021 | Accepted: 15 Feb 2021 | Published online: 16 May 2021

Abstract
Background A decline in the quality of life of mature women, a high prevalence of metabolic syndrome in them, restrictions on the use of hormonal therapy form the need to search for effective and safe methods aimed at reducing the risk of cardiovascular complications and relieving climacteric disorders.
Methods The possibilities of non-drug correction (standard approach, physiotherapy, balneotherapy, multivitamins and minerals, physiotherapy) of metabolic and endocrine disorders in 330 women 45-50 years old with metabolic syndrome (MS) during menopause were studied. The participants were divided into 5 groups depending on the programs used, 2 subgroups - mild and moderate menopausal syndrome (MPS). The levels of follicle-stimulating (FSH), luteinizing (LH) hormones, estradiol, hemostasis, glycemic status, lipid profile, green test, blood pressure (BP), SCORE scale were assessed.
Results In patients with mild MPS, when using programs with physiotherapy, HOMA-IR decreased by 50%, the atherogenic index by more than 25.0%, INR increased by more than 4,0%, the Green score decreased by more than 40.0%, the risk on a SCORE scale became <3%. In patients with moderate MPS, the treatment complex with the simultaneous use of vibrotherapy, chromotherapy, melootherapy, aromatherapy and aeroionotherapy had the advantage: HOMA-IR decreased by 50.5%, atherogenic index by 30,5%, INR increased by 5.0%, the Green score decreased by 40.0%, the risk on a SCORE scale became <3%.
Conclusions In patients with MPS and MS, non-drug programs using physical therapy have a positive effect on the functioning of the endocrine system, hemostasis, carbohydrate and fat metabolism which helps reduce the risk of cardiovascular events. In case of moderate MPS against the background of MS, the program with simultaneous use of vibrotherapy, chromotherapy, melotherapy, aromatherapy and aeroionotherapy has an advantage.

Key words  Menopausal syndrome, metabolic syndrome, metabolic and endocrine disorders, cardiovascular risk