Table of Contents

• Respiratory syncytial virus (RSV): prevention and antiviral therapeutic strategies

  Shahnaz Parveen, Shaikh Salam

  Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infections, particularly among young children and older adults. It specifically targets ciliated epithelial cells, setting off a cascade that includes the release of pro-inflammatory cytokines and the activation of an innate antiviral defense by alveolar macrophages and dendritic cells. Antivirals for the RSV function by pre...

  REVIEW | Published: 22 Feb 2025

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Online First

  Pages: 22-32   PDF(1563KB)   Views：7Downloads：0

• Time matters: chrono-pharmacotherapy as precision medicine

  Samir Arabi, Sajjad Ahmad

  The circadian clock and its inherent rhythms serve as the foundation for regulating many of the body’s vital processes. Recent advances in medicine have leveraged these natural cycles through chronotherapy, the practice of timing drug administration to align with the body's internal clock, to enhance treatment outcomes. Endogenous clocks not only dictate physiological rhythms but also influence ho...

  REVIEW | Published: 20 Feb 2025

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Online First

  Pages: 11-21   PDF(2290KB)   Views：24Downloads：1

• Harnessing exosomes: the future of drug delivery across biological barriers

  Rahul Choudhury

  A unique class of extracellular vesicles (EVs), exosomes range in size from 30 to 150 nm. They frequently travel to distant tissues inside an organism and are essential for cellular communication. Exosomes are useful in the creation of targeted therapeutics for the delivery of macromolecules and drug delivery systems because of their notable natural cell-targeting properties. Because of these feat...

  REVIEW | Published: 26 Jan 2025

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Online First

  Pages: 1-10   PDF(221KB)   Views：91Downloads：2

• Insight into the anti-cancer and anti-viral therapeutic properties of biological active molecule prodigiosin

  Amna Shafqat

  Bioactive compounds from natural sources play an important role as an immunomodulator in diseases such as cancer, inflammatory and viral diseases. Immunomodulator functions to regulate the immune system and defends against infectious foreign particles. Naturally occurring bioactive compounds have been shown to boost the immunity and increase the anti-cancer immune response, as well as in cancer pa...

  REVIEW | Published: 30 Dec 2024

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Volume 4 (2024)

  Pages: 122-136   PDF(3040KB)   Views：127Downloads：2

• GLP-1 receptor agonism in cardiovascular disease prevention

  Hussain Saleh

  Cardiovascular diseases (CVDs) are leading cause of mortality worldwide, closely linked to risk factors such as type 2 diabetes mellitus (T2DM) and obesity. Recent advances in therapeutic strategies have identified glucagon-like peptide-1 receptor agonists (GLP-1RAs) as promising agents that extend beyond glycemic control to offer significant cardiovascular benefits. This review examines the evolv...

  REVIEW | Published: 30 Dec 2024

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Volume 4 (2024)

  Pages: 112-121   PDF(1850KB)   Views：145Downloads：5

• Antigenic switch potential of influenza D virus

  Abdul Bari Hejran, Khaidarov Saken ... Parwiz Niazi

  The antigenic variability of Influenza D virus (IDV), a recently identified pathogen with significant implications for livestock and zoonotic diseases, presents unique challenges in virology, epidemiology, and public health. This review stands out by focusing explicitly on IDV's distinct antigenic shift and drift mechanisms, which are underexplored compared to other influenza viruses. Unlike previ...

  RESEARCH | Published: 01 Dec 2024

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Volume 4 (2024)

  Pages: 95-111   PDF(2360KB)   Views：1121Downloads：12