Table of Contents

• Chlorogenic acid regulates macrophages to improve inflammatory diseases

  Ahmad Karim

  Chlorogenic acid (CGA) is a polyphenolic compound found primarily in coffee and various plants. It has attracted much attention in recent years due to its significant therapeutic potential for regulating immune responses and alleviating inflammatory diseases. Regulation and fine-tuning of macrophage function are key mechanisms of action of CGA as it can effectively promote the polarization of macr...

  REVIEW | Published: 13 Nov 2025

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Online First

  Pages: 65-73   PDF(1650KB)   Views：40Downloads：1

• Bioinformatics-based analysis of Cordyceps Sinensis in the treatment of diabetic nephropathy-associated depression

  Xiaohui Li, Yajun Qiao... Tingting Gao

  Background Diabetic nephropathy (DN) and depression exhibit complex pathological association; yet western medicine shows limited efficacy with notable side effects. Cordyceps sinensis (CS), a traditional Chinese medicine, demonstrates advantages in improving renal function and regulating neuroimmunity, but its mechanism for treating DN with depression remains unclear. Methods Active components of...

  RESEARCH | Published: 10 Oct 2025

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Online First

  Pages: 53-64   PDF(4903KB)   Views：172Downloads：5

• Pharmacokinetics and pharmacodynamics of Tarlatamab, DLL3-Targeted FDA-approved Bispecific T-Cell Engager

  Ahmed Attia Ahmed Abdelmoaty, Ahmed Gamal Badran

  Small-cell lung cancer (SCLC) is a common aggressive cancer type, that exhibits overall lower rate of survival and poor prognosis. Treatment options of SCLC are limited including chemotherapy, radiotherapy, and surgery to dissect tumors. However, these therapies are not very effective in treating SCLCs, and no available therapies are in third-line or beyond. The notch signaling pathway plays a cen...

  REVIEW | Published: 28 Sep 2025

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Online First

  Pages: 44-52   PDF(1530KB)   Views：358Downloads：2

• New developments in the nanocarrier-based drug delivery system for the treatment of breast cancer

  Reem Al Yahyai, Jamilah Al Kalbani

  Worldwide, breast cancer remains the leading cause of disease and mortality for women. Because of its aggressive nature and resistance to conventional medicines, triple negative breast cancer (TNBC) is very challenging to treat. Through focused tactics, recent advancements in nanocarrier technology have demonstrated promise in improving medication delivery, optimizing bioavailability, and raising ...

  REVIEW | Published: 24 Mar 2025

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Online First

  Pages: 33-43   PDF(1480KB)   Views：874Downloads：5

• Respiratory syncytial virus (RSV): prevention and antiviral therapeutic strategies

  Shahnaz Parveen, Shaikh Salam

  Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infections, particularly among young children and older adults. It specifically targets ciliated epithelial cells, setting off a cascade that includes the release of pro-inflammatory cytokines and the activation of an innate antiviral defense by alveolar macrophages and dendritic cells. Antivirals for the RSV function by pre...

  REVIEW | Published: 22 Feb 2025

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Online First

  Pages: 22-32   PDF(1563KB)   Views：721Downloads：9

• Time matters: chrono-pharmacotherapy as precision medicine

  Samir Arabi, Sajjad Ahmad

  The circadian clock and its inherent rhythms serve as the foundation for regulating many of the body’s vital processes. Recent advances in medicine have leveraged these natural cycles through chronotherapy, the practice of timing drug administration to align with the body's internal clock, to enhance treatment outcomes. Endogenous clocks not only dictate physiological rhythms but also influence ho...

  REVIEW | Published: 20 Feb 2025

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Online First

  Pages: 11-21   PDF(2290KB)   Views：1293Downloads：8