Table of Contents

• Effects of xenobiotics on the blood-brain barrier and neural gene expression

  Mark Trussel, Jiff Brad

  The blood-brain barrier (BBB) is a selective barrier that restricts the entry of most substances from the bloodstream into the brain. It consists of three main components: endothelial cells, pericytes, and the astrocytic end-feet. The tight junctions (TJs) between endothelial cells contribute to the barrier's role in preventing many blood-derived substances from crossing into the brain. Xenobiotic...

  REVIEW | Published: 05 Oct 2024

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Volume 4 (2024)

  Pages: 47-54   PDF(1440KB)   Views：186Downloads：5

• Recent approaches in clinical trials of hepatitis C virus vaccine, challenges and future directions

  Muhammad Shoaib Akhtar

  Globally HCV infects more than 170 million individuals and is a major risk of hepatocellular carcinoma, liver cirrhosis and transplantation. Recent antiviral therapy has significant side effects and is much expensive. During the early infection with HCV, the asymptomatic characteristics have a remarkable impact which results in unknowingly spreading HCV. Recently there is no effective vaccine ava...

  REVIEW | Published: 09 Oct 2024

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Volume 4 (2024)

  Pages: 55-64   PDF(1610KB)   Views：132Downloads：6

• Prospects of universal influenza virus vaccine and the current challenges of new antiviral drugs

  Samer K Almadar, Nasser M Alqahtani

  The profound impact of influenza viruses on human health persists as a significant burden, given their potent capacity to cause morbidity and mortality. Despite efforts to mitigate the annual burden of influenza, the effectiveness of current seasonal vaccines in providing substantial protection falls short, leaving undesirable pandemic of influenza viruses. The challenges posed by the influenza pa...

  REVIEW | Published: 09 Oct 2024

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Volume 4 (2024)

  Pages: 65-75   PDF(1230KB)   Views：189Downloads：4

• Progress in the study of toxic effects of drugs on the male reproductive system

  Tina Walker

  This paper provides a comprehensive summary of the toxic effects of drugs on the male reproductive system, with a special focus on the mechanisms of testicular and sperm damage caused by chemotherapeutic agents, antibiotics, and immunosuppressants. Drug-induced reproductive toxicity usually manifests through multiple pathways including direct injury, interference with hormone regulation, oxidative...

  REVIEW | Published: 13 Nov 2024

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Volume 4 (2024)

  Pages: 76-84   PDF(1914KB)   Views：100Downloads：1

• Exploiting senescence as a therapeutic target in osteoarthritis

  Christopher Larbie, Umar Raza

  Osteoarthritis (OA) is a complex degenerative joint disease with significant socioeconomic impact worldwide. Senescence, marked by permanent cell cycle arrest and acquisition of a pro-inflammatory senescence-associated secretory phenotype (SASP), affects chondrocytes, synovial cells and stem cells alike, disrupting cartilage homeostasis and integrity, ultimately contributing to OA pathogenesis and...

  REVIEW | Published: 22 Nov 2024

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Volume 4 (2024)

  Pages: 85-94   PDF(1980KB)   Views：99Downloads：4

• Antigenic switch potential of influenza D virus

  Abdul Bari Hejran, Khaidarov Saken ... Parwiz Niazi

  The antigenic variability of Influenza D virus (IDV), a recently identified pathogen with significant implications for livestock and zoonotic diseases, presents unique challenges in virology, epidemiology, and public health. This review stands out by focusing explicitly on IDV's distinct antigenic shift and drift mechanisms, which are underexplored compared to other influenza viruses. Unlike previ...

  RESEARCH | Published: 01 Dec 2024

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Volume 4 (2024)

  Pages: 95-111   PDF(2360KB)   Views：1015Downloads：9