Table of Contents

• Recent approaches in clinical trials of hepatitis C virus vaccine, challenges and future directions

  Muhammad Shoaib Akhtar

  Globally HCV infects more than 170 million individuals and is a major risk of hepatocellular carcinoma, liver cirrhosis and transplantation. Recent antiviral therapy has significant side effects and is much expensive. During the early infection with HCV, the asymptomatic characteristics have a remarkable impact which results in unknowingly spreading HCV. Recently there is no effective vaccine ava...

  REVIEW | Published: 09 Oct 2024

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Volume 4 (2024)

  Pages: 55-64   PDF(1610KB)   Views：163Downloads：6

• Effects of xenobiotics on the blood-brain barrier and neural gene expression

  Mark Trussel, Jiff Brad

  The blood-brain barrier (BBB) is a selective barrier that restricts the entry of most substances from the bloodstream into the brain. It consists of three main components: endothelial cells, pericytes, and the astrocytic end-feet. The tight junctions (TJs) between endothelial cells contribute to the barrier's role in preventing many blood-derived substances from crossing into the brain. Xenobiotic...

  REVIEW | Published: 05 Oct 2024

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Volume 4 (2024)

  Pages: 47-54   PDF(1440KB)   Views：240Downloads：5

• Insilico toxicity prediction by using ProTox-II computational tools

  Sambasivam Dhinesh Kumar, Rajasekaran. A, K. Suresh Kumar

  Computational methods transform chemical safety assessment, offering efficient toxicity prediction. Swift and accurate analysis improves safety evaluations, benefiting drug development and regulatory compliance. ...

  RESEARCH | Published: 29 Aug 2024

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Volume 4 (2024)

  Pages: 41-46   PDF(755KB)   Views：280Downloads：10

• Evaluating prescription errors and prescribing indicators in the outpatient department of a tertiary care hospital quetta, Pakistan

  Shahbaz Babul, Ghulam Dastagir ... Abdul Wahid

  This study aimed to evaluate prescription patterns, in healthcare settings, particularly in the outpatient department of Sandeman Provencial Hospital in Quetta, Pakistan, is essential for optimizing patient care, promoting rational drug use, and addressing public health challenges....

  RESEARCH | Published: 28 Jul 2024

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Volume 4 (2024)

  Pages: 34-40   PDF(849KB)   Views：348Downloads：10

• Rapamycin reduces testicular ischemia-reperfusion injury by enhancing autophagy

  Zhi Hu, Qiong Cheng ... Wei Zhang

  To confirm the effects of autophagy on testicular ischemia-reperfusion (I/R) injury. Methods Forty rats were divided into sham group, I/R group, I/R+Rap (rapamycin, autophagy activator) group and I/R+ 3-MA (3-methyl adenine, autophagy inhibitor) group. Before inducing ischemia, rapamycin and 3-MA were intraperitoneally injected into I/R+Rap and I/R+ 3-ma groups, respectively. Subsequently, we the...

  RESEARCH | Published: 17 May 2024

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Volume 4 (2024)

  Pages: 26-33   PDF(1599KB)   Views：459Downloads：12

• Isolation and quantification of Scopoletin from leaves and marketed formulation of Morinda citrifolia L.

  K. Suresh Kumar, N. Kiruthiga ... M. Sureka

  Objective This study aims to isolate and quantify Scopoletin in leaves and commercial noni juice products of Morinda citrifolia. Methods TLC and HPTLC methods were developed for the isolation and quantification of Scopoletin. Results The ethanol leaf extract of Morinda citrifolia contains 7.4 mg of Scopoletin per 1 g of extract. Noni juices A, B, and C were found to contain 41 mg, 25.7 mg, and...

  RESEARCH | Published: 02 Jun 2024

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Volume 4 (2024)

  Pages: 18-25   PDF(1430KB)   Views：421Downloads：17