Table of Contents

• Targeting NLRP3 inflammasome-driven neuroinflammation in Alzheimer’s disease

  Yanhua Wang, Hua Li

  Alzheimer’s disease (AD) is a neurological condition, which is marked by cognitive decline and deterioration, leading to memory loss and behavioral disturbances, thefore, badly impacting daily life. Although significant advancements in terms of exploring the causes and underlying molecular mechanisms of AD have been made in recent years, no efficient treatment has been developed so far. Neuroinfla...

  REVIEW | Published: 04 Jan 2026

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Online First

  Pages: 1-10   PDF(1630KB)   Views：147Downloads：3

• Comparative phytochemical analysis of aqueous leaf extracts of locally grown and imported variants of Nicotiana Tabacum in Southeastern Nigeria

  Nelson I. Oguanobi, Chioli P. Chijioke ... Obinna C. Nwoke

  The concentrations of phytochemical constituents in a plant are affected by the environmental factors, cultivation methods and diseases. The specific objective of the study was to analyze and compare the phytochemical composition of dried leaf extracts of foreign and Nigerian locally-grown varieties of Nicotiana tabacum. ...

  RESEARCH | Published: 22 Jan 2026

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Volume 5 (2025)

  Pages: 74-80   PDF(1000KB)   Views：61Downloads：5

• Chlorogenic acid regulates macrophages to improve inflammatory diseases

  Ahmad Karim

  Chlorogenic acid (CGA) is a polyphenolic compound found primarily in coffee and various plants. It has attracted much attention in recent years due to its significant therapeutic potential for regulating immune responses and alleviating inflammatory diseases. Regulation and fine-tuning of macrophage function are key mechanisms of action of CGA as it can effectively promote the polarization of macr...

  REVIEW | Published: 13 Nov 2025

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Volume 5 (2025)

  Pages: 65-73   PDF(1650KB)   Views：153Downloads：3

• Bioinformatics-based analysis of Cordyceps Sinensis in the treatment of diabetic nephropathy-associated depression

  Xiaohui Li, Yajun Qiao... Tingting Gao

  Background Diabetic nephropathy (DN) and depression exhibit complex pathological association; yet western medicine shows limited efficacy with notable side effects. Cordyceps sinensis (CS), a traditional Chinese medicine, demonstrates advantages in improving renal function and regulating neuroimmunity, but its mechanism for treating DN with depression remains unclear. Methods Active components of...

  RESEARCH | Published: 10 Oct 2025

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Volume 5 (2025)

  Pages: 53-64   PDF(4903KB)   Views：269Downloads：8

• Pharmacokinetics and pharmacodynamics of Tarlatamab, DLL3-Targeted FDA-approved Bispecific T-Cell Engager

  Ahmed Attia Ahmed Abdelmoaty, Ahmed Gamal Badran

  Small-cell lung cancer (SCLC) is a common aggressive cancer type, that exhibits overall lower rate of survival and poor prognosis. Treatment options of SCLC are limited including chemotherapy, radiotherapy, and surgery to dissect tumors. However, these therapies are not very effective in treating SCLCs, and no available therapies are in third-line or beyond. The notch signaling pathway plays a cen...

  REVIEW | Published: 28 Sep 2025

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Volume 5 (2025)

  Pages: 44-52   PDF(1530KB)   Views：524Downloads：5

• New developments in the nanocarrier-based drug delivery system for the treatment of breast cancer

  Reem Al Yahyai, Jamilah Al Kalbani

  Worldwide, breast cancer remains the leading cause of disease and mortality for women. Because of its aggressive nature and resistance to conventional medicines, triple negative breast cancer (TNBC) is very challenging to treat. Through focused tactics, recent advancements in nanocarrier technology have demonstrated promise in improving medication delivery, optimizing bioavailability, and raising ...

  REVIEW | Published: 24 Mar 2025

  Asia-Pacific Journal of Pharmacotherapy & Toxicology, Articles, Volume 5 (2025)

  Pages: 33-43   PDF(1480KB)   Views：1004Downloads：6